Effect of 2-hydroxyethylammonium carboxylate protic ionic liquids on the solubility and cytotoxicity of indomethacin

Table 5 The Jouyban–Acree–Van’t Hoff mode’s parameters for the IMC in the aqueous solutions containing PILs

T/K	A₁	10³B₁	A₂	10³B₂	J₀	10^–4 J₁	10^–4 J₂
Indomethacin (1) + (2-hydroxyethylammonium propionate) (2) + water (3)
298.15	38.424	1.625	− 12.197	1.187	3.489	5.047	4.205
303.15	9.608	7.000	− 11.427	4.750	− 1.851	0.923	0.289
308.15	− 1416.0001	53.003	− 11.590	38.001	7.940	0.499	14.170
313.15	− 19.792	0.813	− 11.566	0.594	0.872	− 2.265	− 1.440

T/K	10⁻³A₁	B₁	A₂	B₂	10^–4 J₀	10^–4 J₁	10^–4 J₂
Indomethacin (1) + (2-hydroxyethylammonium acetate) (2) + water (3)
298.15	− 0.166	0.053	− 11.714	0.038	9.993	9.371	4.508
303.15	1.194	0.006	− 11.383	0.005	− 66.690	− 42.770	− 12.430
308.15	− 0.101	0.107	− 11.383	0.077	7.663	9.768	5.343
313.15	− 0.851	0.108	− 11.193	0.077	48.710	31.940	9.754

T/K	A₁	B₁	A₂	B₂	10^–6 J₀	10^–5 J₁	J₂
Indomethacin (1) + (2-hydroxyethylammonium lactate) (2) + water (3)
298.15	− 54.304	0.026	− 10.540	0.019	0.034	0.342	0.191
303.15	− 4540.000	0.108	− 10.583	0.078	2.559	17.330	5.595
308.15	− 2470.002	0.107	− 10.227	0.077	1.399	9.147	2.802
313.15	− 3308.999	0.107	− 10.459	0.077	1.935	13.300	4.420

ISSN: 2661-801X