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Table 6 Results of freezing–thawing and short term stability study for Cytarabine HCl and Dexamethasone in spiked human plasma samples

From: Two chromatographic methods for determination of cytarabine and dexamethazone; two co-administered drugs for the treatment of leukemia: green analytical perspective

 

Concentration (µg /band)

Recovery % a

Three freeze thaw cycles

Bench top stability

 

TLC method

  

CYT

1

104.06

102.58

2

107.29

104.11

4

104.32

104.49

Mean ± SD

105.22 ± 1.79

103.72 ± 1.01

DEX

1

103.72

102.72

2

106.96

104.96

4

104.32

105.65

Mean ± SD

105.00 ± 1.72

104.44 ± 1.53

 

HPLC method

CYT

3

106.53

101.61

8

106.88

102.55

15

104.8

102.33

Mean ± SD

106.07 ± 1.11

102.16 ± 0.49

DEX

3

107.53

102.61

8

106.21

103.35

15

106.05

102.5

Mean ± SD

106.59 ± 0.81

102.82 ± 0.46

  1. a Average of 3 determinations
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BMC Chemistry

ISSN: 2661-801X

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