Environmentally benign liquid chromatographic method for concurrent estimation of four antihistaminic drugs applying factorial design approach

Table 4 Assay results for determination of the RUP, DES, FEX and MKT in pure forms

Analyte	Proposed method			Comparison methods [28, 31, 36]		Analyte	Proposed method			Comparison methods [28, 31, 36]
Analyte	Concn. Taken (μg/mL)	Concn. Found (μg/mL)	% Found^a	Concn. Taken (μg/mL)	% Found^a	Analyte	Concn. Taken (μg/mL)	Concn. Found (μg/mL)	% Found^a	Concn. Taken (μg/mL)	% Found^a
RUP	1.00	1.005	100.50	20.00	98.65	FEX	1.00	0.986	98.60	10.00	101.41
	2.00	2.025	101.25	30.00	101.74		2.00	1.974	98.70	20.00	98.72
	6.00	5.965	99.42	40.00	99.36		8.00	7.904	98.80	30.00	100.42
	8.00	7.901	98.76				10.00	10.180	101.80
	10.00	10.096	100.96				24.00	23.960	99.83
Mean ± SD			100.18 ± 1.05		99.92 ± 1.62	Mean ± SD			99.55 ± 1.35		100.18 ± 1.36
t			0.28 (2.45)^b			t			0.64 (2.45)^b
F			2.35 (6.94)^b			F			1.01 (6.94)^b
DES	1.00	1.003	100.30	40.00	99.44	MKT	1.00	1.014	101.40	40.00	99.68
	2.00	2.009	100.45	50.00	100.87		2.00	1.986	99.30	50.00	100.54
	6.00	5.904	98.40	60.00	99.65		6.00	5.957	99.28	60.00	99.77
	8.00	8.134	101.68				8.00	8.076	100.95
	10.00	9.948	99.48				10.00	9.966	99.66
Mean ± SD			100.06 ± 1.22		99.99 ± 0.77	Mean ± SD			100.12 ± 0.99		100.00 ± 0.47
t			0.09 (2.45)^b			t			0.19 (2.45)^b
F			2.48 (19.25)^b			F			4.38 (19.25)^b

ISSN: 2661-801X