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Fig. 4 | BMC Chemistry

Fig. 4

From: Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression

Fig. 4

2D interaction diagrams showing the binding profile of both the protein signatures A(i-v) AKT1 and B(i-v) MDM2 with their top five screened candidate drugs: Tadalafil, Paliperidone, Sertindole, Troglitazone, Cobimetinib, Drospirenone, Finasteride, and Loratadine. The binding affinities are measured in kcal/mol (given in brackets). Intramolecular interactions are depicted as colored dashed lines between protein residues and drug atoms. The solvent-accessible surface of an interacting residue is represented by a blue halo around the residue

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BMC Chemistry

ISSN: 2661-801X

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