Smart chemometrics-assisted spectrophotometric methods for efficient resolution and simultaneous determination of paracetamol, caffeine, drotaverine HCl along with three of their corresponding related impurities

Table 6 Statistical analysis of the results obtained by the proposed chemometric methods and the reported method for the determination of paracetamol, caffeine and drotaverine hydrochloride in their pharmaceutical formulation

Item	PCR			PLS			siPLS			Reported method* [19]
Item	PAR	CAF	DRO	PAR	CAF	DRO	PAR	CAF	DRO	PAR	CAF	DRO
Mean	104.37	94.67	96.85	103.78	99.31	97.35	104.05	98.21	103.00	102.17	97.2	98.34
SD	1.698	2.032	2.059	2.125	1.833	1.268	0.982	2.063	1.789	1.751	1.456	1.128
Variance	2.883	4.129	4.239	4.516	3.360	1.608	0.964	4.256	3.201	3.066	2.120	1.272
An	5	5	5	5	5	5	5	5	5	5	5	5
Student’s t-test (2.306)^**	2.017	2.263	1.419	1.307	2.015	1.304	2.094	0.894	0.751
F value (6.39)^**	1.063	1.948	3.332	1.473	1.585	1.264	3.180	2.008	2.517

^** Figures in parentheses are the corresponding tabulated values for t and F at p = 0.05
*HPLC method using C₈ column with mobile phase composed of methanol: 0.02 M sodium dihydrogen phosphate (50:50, v/v) at a flow rate of 1.0 mL/min and UV detection wavelength at 220.0 nm

ISSN: 2661-801X