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Table 5 Determination of paracetamol, caffeine and drotaverine hydrochloride in their pharmaceutical formulation using the proposed chemometric methods and the results of standard addition technique

From: Smart chemometrics-assisted spectrophotometric methods for efficient resolution and simultaneous determination of paracetamol, caffeine, drotaverine HCl along with three of their corresponding related impurities

Pharmaceutical formulation

Compound

PCR

PLS

siPLS

Founda % ± SD

Petro® tablets

PAR

104.37 ± 1.698

103.78 ± 2.125

104.05 ± 0.982

CAF

94.67 ± 2.032

99.31 ± 1.833

98.21 ± 2.063

DRO

96.85 ± 2.059

97.35 ± 1.268

103.00 ± 1.789

Standard addition

PAR

99.99 ± 1.342

100.51 ± 1.892

99.98 ± 1.698

CAF

100.65 ± 1.768

99.18 ± 0.970

99.62 ± 0.589

DRO

99.50 ± 1.137

100.22 ± 1.660

100.52 ± 1.288

PAP

98.47 ± 0.686

99.82 ± 1.617

99.58 ± 1.838

THEO

97.25 ± 0.922

98.99 ± 1.773

98.06 ± 1.007

HVA

100.65 ± 1.768

99.98 ± 1.698

97.02 ± 1.917

  1. aAverage of five determinations