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Table 2 Statistical and linear regression parameters for the validation set using PCR and PLS models

From: Smart chemometrics-assisted spectrophotometric methods for efficient resolution and simultaneous determination of paracetamol, caffeine, drotaverine HCl along with three of their corresponding related impurities

Parameters

PCR

PLS

PAR

CAF

DRO

PAP

THEO

HVA

PAR

CAF

DRO

PAP

THEO

HVA

Mean recovery %

99.95

99.52

100.59

99.29

100.59

99.52

100.15

99.67

100.84

99.54

100.69

99.97

SD

1.362

3.614

4.698

2.207

2.438

1.394

1.216

3.404

1.665

2.471

2.2468

1.376

RSD %

1.362

3.631

4.671

2.223

2.424

1.401

1.214

3.415

1.651

2.482

2.231

1.376

RMSEP

0.11851

0.12493

0.12992

0.04278

0.06930

0.04034

0.12922

0.11551

0.05668

0.04232

0.05858

0.04006

Correlation coefficient (r)

0.9976

0.9910

0.9795

0.9966

0.9921

0.9970

0.9976

0.9930

0.9984

0.9966

0.9935

0.9973

Slope

1.0045

0.9304

0.9617

0.9720

1.0245

0.9950

0.9759

0.9295

1.0353

0.9666

0.9877

0.9707

Intercept

− 0.0475

0.2326

0.1145

0.0371

− 0.0435

0.0003

0.2772

0.2419

− 0.0656

0.0518

0.0433

0.0896

LODa

0.077

0.416

0.524

0.078

0.248

0.148

0.384

0.365

0.129

0.092

0.227

0.147

LOQa

0.234

1.257

1.289

0.238

0.752

0.449

1.064

1.106

0.390

0.278

0.688

0.447

  1. aCalculated from equation [LOD (limit of detection) = 3.3 (SD/S), LOQ (limit of quantification) = 10 (SD/S); where SD is the standard deviation of regression residuals and S is the slope of the calibration curves
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BMC Chemistry

ISSN: 2661-801X

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