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Table 1 Concentration of the six studied components in the calibration and validation sets

From: Smart chemometrics-assisted spectrophotometric methods for efficient resolution and simultaneous determination of paracetamol, caffeine, drotaverine HCl along with three of their corresponding related impurities

Samples

Concentration (µg/mL)

PAR

CAF

DRO

PAP

THEO

HVA

1

7.80

4.20

2.60

2.00

2.50

3.50

2

7.80

1.40

2.00

1.00

3.50

4.50

3

1.00

2.80

1.40

3.00

3.50

3.50

4

4.40

1.40

3.80

3.00

2.50

3.00

5

1.00

7.00

3.80

2.00

2.00

4.50

6

14.60

7.00

2.60

1.50

3.50

3.00

7

14.60

4.20

2.00

3.00

2.00

4.00

8

7.80

2.80

3.80

1.50

3.00

4.00

9

4.40

7.00

2.00

2.50

3.00

3.50

10

14.60

2.80

3.20

2.50

2.50

4.50

11

4.40

5.60

3.20

2.00

3.50

4.00

12

11.20

5.60

2.60

3.00

3.00

4.50

13

11.20

4.20

3.80

2.50

3.50

2.50

14

7.80

7.00

3.20

3.00

1.50

2.50

15

14.60

5.60

3.80

1.00

1.50

3.50

16

11.20

7.00

1.40

1.00

2.50

4.50

17

14.60

1.40

1.40

2.00

3.00

2.50

18

1.00

1.40

2.60

2.50

1.50

4.00

19

1.00

4.20

3.20

1.00

3.00

3.00

20

7.80

5.60

1.40

2.50

2.00

3.00

21

11.20

1.40

3.20

1.50

2.00

3.50

22

1.00

5.60

2.00

1.50

2.50

2.50

23

11.20

2.80

2.00

2.00

1.50

3.00

24

4.40

2.80

2.60

1.00

2.00

2.50

25

4.40

4.20

1.40

1.50

1.50

4.50

  1. The italics samples are those selected for external validation