Higher sensitive selective spectrofluorometric determination of ritonavir in the presence of nirmatrelvir: application to new FDA approved co-packaged COVID-19 pharmaceutical dosage and spiked human plasma

Table 5 Comparative evaluation of the described method with previously reported spectrophotometric method

Parameters	Proposed method	Reported method [11]
Solvent	Ethanol	Methanol
Matrix	Pharmaceutical form and spiked plasma	Pharmaceutical form
Linearity range	2.0 − 20.0 ng/mL	10.0 − 20.0 µg/mL
LOD	0.146 ng/mL	1.100 µg/mL
LOQ	0.444 ng/mL	3.300 µg/mL

ISSN: 2661-801X