Fig. 9

Simple 2D diagram of the predicted binding modes of compound 18 the ATP binding domain of PDGFRα (PDB: 5GRN); illustrating the two main hydrogen bonding interactions of compound 18 with Cys694 in hinge domain, and various π-π stacking interactions with Leu599, Val607, Leu825, and Phe837 amino acids residues adjacent to the adenine binding site