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Table 1 Cytotoxic IC50 values of the tested compounds against HepG2 and THLE2 cell lines using the MTT assay

From: Synthesis of novel mono- and bis-pyrazolylthiazole derivatives as anti-liver cancer agents through EGFR/HER2 target inhibition

Compounds

IC50 ± SDa (µM)

HepG2

THLE2

6

16.3 ± 0.29

34.5 ± 1.26

8a

8.64 ± 0.29

46.2 ± 2.01

8b

8.16 ± 0.34

41.6 ± 1.86

8c

7.39 ± 0.29

 ≥ 50

8d

11.3 ± 0.34

 ≥ 50

12

5.48 ± 0.66

 ≥ 50

13

5.16 ± 0.29

 ≥ 50

14

4.36 ± 0.38

39.5 ± 1.74

18a

8.34 ± 0.48

39.8 ± 1.59

18b

3.57 ± 0.67

 ≥ 50

18c

0.97 ± 0.09

 ≥ 50

21a

3.26 ± 0.14

 ≥ 50

21b

9.36 ± 0.47

49.4 ± 2.1

21c

4.12 ± 0.19

45.6 ± 1.87

Lapatinib

7.45 ± 0.32

 ≥ 50

  1. aValues are expressed as Mean ± SD of three independent triplets (n = 3)
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BMC Chemistry

ISSN: 2661-801X

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